So long term use, and in some individuals even short term use, can cause weird shit, decreased test, anhedonia, CFS, both fertility and libido issues, brain fog. It's highly suppressive/depressive. So yeah it mellows you out, but low dose t3+t4 is cheap af, well tested and can keep your TSH healthy and thyroid enzymes in a super happy place. For stress some simple supps like magnesium, theanine, vit d, chamomile extract/apigenin (at low doses, as it's also gabapergic) and rhodia can be pretty effective, especially in tandem. Also if your BP is high, when I started treating that, it helped my stress levels astronomically
Magnesium I will never take because it cramps me up hectically. Fertility has been gone for years, my natural testosterone production is gonzo, my pre-workout has a decent shot of L-theanine, and I absolutely despise T3.
I have plenty of T4 and from practical testing, my body’s natural T3 sees higher up-regulation throughout the day than taking 40mcg of T3. 60-80 I would not be willing to daily, let alone take at all. I wouldn’t even be willing to daily 40 tbh. To be dead honest I wouldn’t take a good dose of T3 even if I was competing, unless a pro card was on the table and I actually had a decent shot (never days).
On 40mcg I believe I was a few ticks above dead average on the range, so 40 does nearly fuckall. I was on T3 for around 7 months and after coming off my metabolism increased and my caloric requirements increased. The only cool thing I experimented with was starving myself on 0 carb with T3. Quite a freakin’ experience.
Currently my mood regulation on/off ashwaghanda doesn’t seem at all better or worse. Back in 2015-2016 I had quit training and I hadn’t yet even heard of it, and I was the most down I’d ever been in my life. If you find that ashwaghanda does affect you negatively then for sure stay away from it. In my particular case it poses basically no harm to me.
Final bit on T3:
IMO augmenting with AAS or any sort of GH-based protein-peptide is somewhat safe because you can acquire different esters relatively easily, and the processes of growth and repair are largely uncontrollable and occur sporadically. You can’t really ever be sure when your body requires a peek level of a hormonal protein-peptide like IGF or an AAS like Test/Nandralone.
With T3, it’s a bit like insulin. You have no idea when your body will require more T3 to up-regulate mitochondrial respiration. I.e., I used to get super low at times of the day because my T3 levelled off at an unideal time. The metabolic system of the body occurs 24/7 as we’re basically always eating (well at least I am), and I can’t really see a justifiable reason to take control of my own active metabolism when I don’t know when the nutrients are hitting me or when my body requires a higher peek.
Augmenting with synthetic T3 is like setting a static OC on a Ryzen CPU whereas allowing your body to take the wheel and using something that up-regulates the conversion rate with respect to when your body wants to up-regulate it, is like running a sick PBO config. To me the only logical use of T3 is when you’re medically low because your thyroid is shot, or during the latter stages of a harsh contest prep during which your body is heavily down-regulating T4 conversion when your body fat % is well below your set point. Just my two cents, but yeah, I don’t like T3 at all. Not to mention if you run out of the drug and your thyroid ends up dormant - not probable but not impossible - you’re pretty much going to be stuck on 1000 calories per day or you’re going to gain significant amounts of fat until it kicks back into gear.
T4 and TSH are chill though, if for some reason your pituitary and your thyroid aren’t coordinating to create the power supply/raw materials necessary for conversion into active.